Calphostins, novel and specific inhibitors of protein kinase C. II. Chemical structures.
نویسندگان
چکیده
The structures of new antitumor antibiotics, calphostins (UCN-1028) A, B, C, D and I, which are specific and potent inhibitors of protein kinase C, were determined by spectral and chemical studies. All of the antibiotics have a 3,10-perylenequinone skeleton and calphostin D was revealed to be an antipode of isophleichrome.
منابع مشابه
Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physico-chemical properties and biological activities.
A novel complex of calphostin (UCN-1028), which specifically inhibits protein kinase C (PKC) has been isolated from the culture broth of a fungi Cladosporium cladosporioides. Purification of individual components was carried out by silica gel, non-porus resin Diaion HP-20SS and Sephadex LH-20 chromatography, leading to isolation of five closely related components. A, B, C, D and I. Calphostins ...
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 42 10 شماره
صفحات -
تاریخ انتشار 1989